What is PDRN and How Does It Work?

PDRN is the new sensation in skincare, and rightly so, as it is a true multitasker that addresses various skin concerns, leaving the skin supple, youthful, and radiant. Dr. Rashmi Shetty prefer using PDRN when overall rejuvenation is needed, especially in cases involving pigmentation issues. At times, doctor combines PDRN with hyaluronic acid or other active ingredients to achieve the best results, depending on the patient’s needs and the condition of their skin when they come to me.

Polydeoxyribonucleotide (PDRN) consists of DNA fragments extracted from the sperm cells of salmon trout.It is a minimally invasive injectable treatment designed to promote angiogenesis, collagen synthesis, soft tissue regeneration, skin revitalization and pigmentation reduction.

The mechanism of action of PDRN involves the activation of A2A receptor which modulates the inflammatory response and improve tissue repair and healing by markedly increasing the expression of the vascular endothelial growth factor (VEGF), a master regulator of angiogenesis.
Also, it causes suppression of melanogenesis through the inhibition of melanogenic gene expression and tyrosinase enzymatic activity.

The following general guidelines are provided to help you plan your social calendar accordingly and ensure optimal healing and results.

What Is the Procedure Like?
The procedure typically takes 15-20 minutes or less and involves the following steps:
1. The treatment area is thoroughly cleansed, and an ice pack or numbing cream is applied, depending on the patient’s sensitivity.
2. Dr. Rashmi Shetty administers the treatment using a very fine needle.
3. Post-procedure, the team ensures your comfort by gently massaging the treated area.

What Can I Expect?
– Improved skin texture
– Oxidative damage repair
– Hair regeneration
– Enhanced healing
– Brighter and more even skin tone
– Improved elasticity
– Overall skin rejuvenation

When Will I See Results?
Results may become noticeable a few weeks after the procedure. However, optimal outcomes are typically achieved after 3-4 sessions spaced 1-2 months apart.

How Long Do the Results Last?
The longevity of results depends on the number of sessions and treatment frequency, which Dr. Rashmi Shetty will determine during your consultation. Generally, results last between 3-6 months.

Are There Any Risks?
Although rare, potential side effects may include mild inflammatory reactions, temporary bumps, bruising, or discoloration at the injection site. These effects typically resolve on their own within a week. Complications are uncommon.

Pre – procedure:
• Limit sun exposure for at least 1-2 weeks before the procedure. Use a broad-spectrum sunscreen (SPF 30+).

• Stop using retinoids, AHAs, BHAs, or exfoliating agents 3-5 days before treatment.

• Avoid smoking and alcohol consumption for at least 48 hours before the procedure to promote better healing.

Post – procedure:

• Avoid sun exposure and always apply sunscreen with SPF 50+ to protect the treated area.

• Skip makeup, retinoids, AHAs/BHAs, and exfoliants for 24-72 hours post-procedure, depending on the treatment.

• Avoid showering or activities that induce perspiration for at least 8 hours post-treatment.

• Postpone other hair or skin treatments for one week.

• Avoid washing your hair or applying products for at least 12 hours.

Comprehensive instructions will be provided during your visit to the clinic to ensure you have a clear understanding of your treatment plan.

• Consult Dr. Rashmi Shetty before using any skin or hair care products.

Enhancing Results with Additional Treatments

• Injectables – Skin booster, Profhilo, Skinvive, Botox, Fillers, NCTF, Mesotherapy
• Energy based devices – IPL, Q switched laser
• Facials – Hydrafacial, 360 facial, glow facial, Medi facial

Supplements:

• Ra Defence: Strong anti- inflammatory properties, thereby making it able to work on reducing and preventing issues related to inflammation that includes, pigmentation, hairfall, skin sensitivity, acne, etc.

• Ra Vitamin C+: Anti-oxidant and anti- inflammatory properties promotes a healthy scalp, follicle function, and radiant skin.

• Ra Hydrate: To hydrate skin and hair from within, promoting youthful and supple skin and shiny hair.

• Ra Primrose: Provides moisture to the skin from within while also balancing hormones.

• Ra Bright: Promotes brighter, glowing skin while addressing issues like pigmentation and uneven skintone.