Profhilo vs. Dermal Fillers:

Understanding the Difference

Have you been hearing things like fillers migrating across the face, lasting forever, or giving an unnatural look? Maybe you’ve even come across terms like “bio-stimulators” and felt lost in the jargon.
You love the idea of enhancing your face—but with so much information (and misinformation) out there, it’s hard to know what’s right for you.
Let’s break it down. Here’s Dr. Rashmi Shetty’s take on what Profhilo and dermal fillers actually do—how they work, how they’re different, and which one might be right for you.

What is Profhilo?

Profhilo is a skin booster, designed to improve skin quality rather than add volume. Unlike traditional fillers, Profhilo is not cross-linked, meaning it does not stay in one place to provide structure or contouring. Instead, it spreads beneath the skin, stimulating collagen and elastin production for deep hydration and overall skin rejuvenation.
What to Expect from Profhilo
Deep hydration: Profhilo improves the skin’s ability to retain moisture, making it appear naturally plump and radiant.
Collagen stimulation: Over time, it enhances skin firmness and elasticity, reducing the appearance of fine lines and wrinkles.
Gradual but natural results: Unlike fillers, the effects of Profhilo are not immediate. Results develop over a few weeks as the skin rebuilds its own support structure.
Minimal downtime: Some mild swelling or small bumps may appear at injection sites, but they typically subside within 24 hours.
Treatment frequency: Depending on skin condition, multiple sessions may be required. Most individuals need two sessions spaced one month apart, followed by maintenance every six months to a year.

What are Dermal Fillers?

Dermal fillers are designed to restore volume, contour, and lift specific facial features. Unlike Profhilo, which spreads beneath the skin, fillers stay in place to sculpt and enhance areas like the cheeks, lips, jawline, and under-eyes.
What to Expect from Fillers
Immediate enhancement: Fillers provide instant results, making them ideal for quick aesthetic transformations.
Volume and structure: Fillers restore lost volume, helping to lift sagging skin, fill hollow areas, and smooth deep wrinkles.
Customizable results: The amount and type of filler can be tailored based on your goals—whether it’s subtle enhancement or dramatic definition.
Mild side effects: Some swelling, bruising, or tenderness can occur but typically resolves within a few days.
Longevity of results: Depending on the type of filler used, results can last six months to two years before requiring a touch-up.

More Than Just Science—It’s an Art

Sounds simple and technical? It’s really not. Aesthetic medicine is as much an art as it is a science.
When it comes to Profhilo, the technique makes all the difference—it determines how effectively your skin gets rejuvenated and stimulated.
With fillers, it’s all about personalisation. Every face is unique, and so are the enhancements. Beautiful, subtle, natural-looking results come from knowing exactly what to highlight—without making it obvious something was done. The mystery of “how is she glowing like that?”—that takes experience, vision, and a lot of individual thought.

Key Takeaways

While both Profhilo and fillers contain hyaluronic acid, they serve different purposes. Profhilo boosts hydration, improves skin elasticity, and stimulates collagen, delivering gradual, natural-looking results. Fillers, on the other hand, add volume and contour instantly, enhancing features like the cheeks, lips, and jawline.
If your goal is deep skin hydration and firming, Profhilo is ideal. For restoring lost volume or defining facial structure, fillers work best. Often, a combination of both provides optimal results.
The best approach? Consult an experienced aesthetic doctor who understands your skin, your structure, and your story.

Each article is written after detailed discussions and notes from Dr. Shetty

Dr. Rashmi Shetty
Cosmetic Dermatologist,
Mumbai | Hyderabad

Dr. Rashmi Shetty is a celebrity dermatologist, industry pioneer, author , globally invited teaching faculty and a leading expert in aesthetic medicine having over 20 years of experience in aesthetic and clinical dermatology. She is the Founder and chief dermatologist at Ra Skin and Aesthetics in Mumbai and Hyderabad. She is named the best Dermatologist by Vogue 2020 and is the first Indian doctor on the International Advisory board of the Anti-Ageing World Congress, FACE London, ICAD Asia, and honorary faculty at UCL .

 For more such tips and information from Dr Rashmi Shetty, follow her on

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You can also call on 09833055236 to book an appointment

If you have any questions or clarifications after reading this article, please comment.

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